Female hormonal factors and the risk of endometrial cancer in Lynch syndrome

SG Dashti; R Chau; DA Ouakrim; DD Buchanan; M Clendenning; JP Young; IM Winship; J Arnold; DJ Ahnen; RW Haile; G Casey; S Gallinger; SN Thibodeau; NM Lindor; L Le Marchand; PA Newcomb; JD Potter; JA Baron; JL Hopper; MA Jenkins; AK Win

Journal article

Female hormonal factors and the risk of endometrial cancer in Lynch syndrome

SG Dashti, R Chau, DA Ouakrim, DD Buchanan, M Clendenning, JP Young, IM Winship, J Arnold, DJ Ahnen, RW Haile, G Casey, S Gallinger, SN Thibodeau, NM Lindor, L Le Marchand, PA Newcomb, JD Potter, JA Baron, JL Hopper, MA Jenkins Show all

JAMA Journal of the American Medical Association | AMER MEDICAL ASSOC | Published : 2015

DOI: 10.1001/jama.2015.6789

Abstract

IMPORTANCE: Apart from hysterectomy, there is no consensus recommendation for reducing endometrial cancer risk for women with a mismatch repair gene mutation (Lynch syndrome). OBJECTIVE: To investigate the association between hormonal factors and endometrial cancer risk in Lynch syndrome. DESIGN, SETTING, AND PARTICIPANTS: A retrospective cohort study included 1128 women with a mismatch repair gene mutation identified from the Colon Cancer Family Registry. Data were analyzed with a weighted cohort approach. Participants were recruited between 1997 and 2012 from centers across the United States, Australia, Canada, and New Zealand. EXPOSURES: Age at menarche, first and last live birth, and men..

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University of Melbourne Researchers

Ghazaleh Dashti Author

Driss Ait Ouakrim Author

Daniel Buchanan Author

Mark Clendenning Author

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Grants

Awarded by National Institutes of Health

Funding Acknowledgements

This work was supported by grant UM1 CA167551 from the National Cancer Institute, National Institutes of Health, and through cooperative agreements with members of the Colon Cancer Family Registry and principal investigators. Collaborating centers include the Australasian Colorectal Cancer Family Registry (U01/U24 CA097735), Mayo Clinic Cooperative Family Registry for Colon Cancer Studies (U01/U24 CA074800), Ontario Familial Colorectal Cancer Registry (U01/U24 CA074783), Seattle Colorectal Cancer Family Registry (U01/U24 CA074794), Stanford Consortium Colorectal Cancer Family Registry (U01/U24 CA074799), and University of Hawaii Colorectal Cancer Family Registry (U01/U24 CA074806). This work was also supported by Centre for Research Excellence grant APP1042021 and program grant APP1074383 from the National Health and Medical Research Council (NHMRC), Australia. Dr Win is an NHMRC Early Career Fellow. Dr Jenkins is an NHMRC Senior Research Fellow. Dr Hopper is an NHMRC Senior Principal Research Fellow. Dr Buchanan is a University of Melbourne Research at Melbourne Accelerator Program Senior Research Fellow.